What is Duloxetine and what is it used for?
Duloxetine is an active substance that increases the levels of serotonin and noradrenaline in the nervous system.
For this reason, Duloxetine capsules are used for the following pathologies:
- Major Depressive Disorder
- Generalized Anxiety Disorder (GAD)
- Diabetic Peripheral Neuropathy
- Fibromyalgia and chronic pain
What you have to know before taking Duloxetine
Duloxetine is part of a new type of antidepressant that acts both on noradrenaline circuit and on 5-HT. The side effects are similar to those of SSRI (serotonin reuptake inhibitors). If the medication is interrupted, it may cause the symptoms of a withdrawal syndrome that requires the slow decrease in the required dosage.
Is important to note how depression is associated to a higher risk of suicidal and self-harming thoughts and behaviors, and before Duloxetine will take effect, 24-48 weeks of treatment will be necessary. For those reasons, the patient needs to be accurately monitored until the illness starts to be in regression.
Also, Duloxetine shouldn’t be prescribed to young patients (under 18 years old) because this medicine increases the risk of suicide tendencies and hostile-aggressive behaviors, even though this is at the specialist’s discretion.
Considering that Duloxetine may cause dizziness and sleepiness, it’s suggested not to drive and not to use machineries during the treatment.
The use of Duloxetine should be avoided if the patient is already taking other drugs containing the same active substance and in patients that suffer the following pathological conditions:
- Kidney diseases
- Maniac disorders
- Bipolar disorders
- Alterations of coagulation
It is highly suggested to inform the specialist if the patient is following other medical treatments.
The side-effects of Duloxetine
Duloxetine may have adverse effects, based on the sensitivity of each individual to the active substance. Those side-effects may include:
- Allergic reactions
- Nervous system diseases
- Psychiatric disorders
- Gastrointestinal disorders
- Reproductive system disorders
- Endocrine disorders
- Eyes and ears disorders
- Renal and urinary disorders
- Symptoms related to the suspension of the treatment
Suggested dosage for Duloxetine
Duloxetine can be administered through the oral cavity, and the capsule has to be swallowed in whole, without chewing.
The amount of Duloxetine has to be decided by the specialist, on an individual basis, but usually the dosage of the drug is 60 mg./day for depression and neuropathic disorders, while for Generalized Anxiety Disorder it may vary between 30 and 120 mg./day.
For more information on Duloxetine 30 mg – 60 mg Gastro-Resistant capsules please consult valpharma.com website.